Monthly Archives: January 2014

ISIS success story from Africa

ivf-africaTrois Mois du bébé Théophile :: FROM AFRICA!
Dear Dr Shivani and Team at ISIS Hospital and Joseph
Thank you very much for the bottom of our hearts for our bundle of joy. After many years of trying and heartbreak now our hearts are full of joy
May you continue your good work for many others

Grateful parents

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Male Factors in Infertility

More often than not, when looking at infertility, it is often believed to be a “Women’s issue”, with the female partner having numerous tests to discover the cause.

It often comes as a huge shock to discover not only does the male partner contribute to infertility, studies indicate that 35% of infertility is related to male factor problems such as structural abnormalities, sperm production disorders, ejaculatory disturbances and immunologic disorders.

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Egg Quality and Pregnancy.

Fertility isn’t fair. It doesn’t matter how fit you are; how young you look or your family history – your egg quality will diminish with age.

A woman is born with about one million eggs, but by the time she has her first period she has lost 60 % of this reserve. These remaining eggs lie dormant inside a woman’s ovaries, waiting to become activated by hormones, during the monthly cycle (if the woman is going through in vitro fertilization, or IVF, the eggs become activated by hormone treatments used to induce ovulation).

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Sperm Quality and Miscarriage

Does sperm quality impact on embryo quality and miscarriage? If you look at the research, you would be mistaken in thinking that everything is dependent on the age of the mother and ova quality, but you would be mistaken.

Half of the chromosomal information for your embryo comes from the father.  There is evidence to suggest that recurrent miscarriages seem to involve the father having a high incidence of abnormal chromosomes in his sperm– especially in men whose sperm show abnormal morphology or other markers of low fertility.

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Egg Donation: History and Procedure followed by ISIS:

The history of Egg Donation is very interesting. Literature reports that the first egg donor was 42 years old! In 1983, She was doing and IVF Cycle for herself and out of 6 follicles 5 oocytes were retrieved of which she donate one and used 4 for her own IVF treatment. She did not get pregnant, the recipient did get pregnant but unfortunately the pregnancy miscarried due to a genetic abnormality (47 XXY) in the embryo (which could be attributed to the genetic mother’s age). In this cycle no hormonal preparation was used in the recipient.

The next pregnancies were reported by Buster et all from USA in the same year 1983, the methods used would certainly raise a minefield of controversy today. The egg donors were inseminated with the sperm of the recipient’s husband ( IUI). The resultant embryos were then removed from the uterus of the egg donor by lavage (wash) and then were transferred in the recipient’s uterus. The recipients all had failed IVFs in the past and were ovulating regularly more details are given below. One of the egg donor did have a retained pregnancy which aborted naturally!

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