The history of Egg Donation is very interesting. Literature reports that the first egg donor was 42 years old! In 1983, She was doing and IVF Cycle for herself and out of 6 follicles 5 oocytes were retrieved of which she donate one and used 4 for her own IVF treatment. She did not get pregnant, the recipient did get pregnant but unfortunately the pregnancy miscarried due to a genetic abnormality (47 XXY) in the embryo (which could be attributed to the genetic mother’s age). In this cycle no hormonal preparation was used in the recipient.
The next pregnancies were reported by Buster et all from USA in the same year 1983, the methods used would certainly raise a minefield of controversy today. The egg donors were inseminated with the sperm of the recipient’s husband ( IUI). The resultant embryos were then removed from the uterus of the egg donor by lavage (wash) and then were transferred in the recipient’s uterus. The recipients all had failed IVFs in the past and were ovulating regularly more details are given below. One of the egg donor did have a retained pregnancy which aborted naturally!
For Ovarian failure the first egg donation cycle resulted in a positive pregnancy in 1984, exogenous steroid hormones copying the pattern of a normal cycle were used by the recipient.
Currently in India, only Anonymous egg donation is allowed under the National ICMR Guidelines www.icmr.nic.in.
The Indian egg donors are sourced by ART Banks who recruit, look after treatment under instructions from an IVF Specialist and also compensate the egg donor. Form M 1 in the ICMR Website is to be filled for all egg donors by the ART Bank. Along with these consents in Local Language are also done in the program we work with. An initial consent is also taken by the ART Bank (FCI – Fertility Care India etc) which advises the egg donor of the procedure of tests and possibility of not being accepted in the program if the tests are not satisfactory. The risks involved in this procedure are also discussed. At the time of egg donation the consent form from the ICMR website is signed. This form requires the details of the psychologist and date of the counseling session to be mentioned. In our program a Gynaecologist, an IVF Specialist and a Qualified Post graduate Psychologist are involved in the process of medical checks to confirm the suitability of the Egg donor for the program. Both Agonist and Antagonist programs work well in our experience. All the injections are given by Hospital staff so as to confirm regular injections being taken by the donor, injections being given properly and not wasted and any problems etc can be picked up early.
Curr Opinion in OB/ GYN 1995, 7, 193-198: Sauer/ Paulson
Aspects: Westmed Journal:: John Buster MD: Non surgical transfer
- During the period from Jan 1983 – 84, 11 donor women and 14 infertile recipient couples participated.
- The ovum recipients were married women between the ages of 23 and 36 years. They were regularly ovulating, free of major medical or psychiatric problems and standard surgical therapy for tubal infertility had failed. All recipient women had a history of infertility of more than three years. Husbands had semen analyses with sperm count of at least 20 million per milliliter.
- Ovum donors were fertile women ages 26 through 35 years who were ovulating regularly and free of major medical or psychiatric disorders. There were 43 lavage sequences with recovery of 18 ova(42%).
- There was one retained donor pregnancy that aborted spontaneously nine days after a missed menstrual flow.
- Of the 18 ova, 2 were undivided, 10 contained between 2 and 14 blastomeres, 3 were morula and 3 were blastocysts. All ova were transferred. Two of the recipient women became pregnant and have enjoyed uneventful obstetric courses. One woman was delivered of a full-term healthy child as of February 1984. The second was delivered of a normal healthy child shortly thereafter. The third had an ectopic gestation.
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